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However, the benefits have not been reproduced in clinical applications, this may be attributed to the limited absorption, concentration, and half-life of exogenous antioxidants

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Magnetic resonance spectroscopy (MRS) techniques have also been used to study energy metabolism [29 MRS enables the measurement of metabolic pathway rates and metabolite concentrations, however its low sensitivity and limited spatial resolution do not allow for precise characterization and mapping of metabolic pathways in the whole brain [34, 35]

Dupuis, L., Pradat, P.-F., Ludolph, A