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Periodontitis is an inflammatory disease of the gums and supporting tissues of the teeth lead by the addition of dental plaque ( To much production of oxidants results into oxidative damage to cells and matrix molecules in the gingival tissues, like lipid peroxidation, protein oxidation, and DNA damage, aggravating the severity and duration of the inflammatory response ( 2.3 Role of oxidative stress in the pathogenesis of periodontitis In the pathogenesis of periodontitis, oxidative stress is of great importance

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However, since cuprizone is a heat sensitive compound, it is important to pay attention to temperature conditions when preparing the pellets

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