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It is noteworthy that supplementation with iron-modulating agents does not effectively reduce hepatic iron stores and is anticipated to garner significant interest as a novel therapeutic strategy for addressing the pathogenesis of hemochromatosis [108, 109]

GSH depletion does not induce mitochondrial superoxide or alter mitochondrial mass in RPE cells It has been suggested that mitochondria are predominant source of ROS upon H 2 O 2 -induced oxidative stress 7

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Second, arsenic was analysed using Hydride Generation Atomic Absorption Spectrophotometry (HGAAS), which involves the conversion of all arsenic to As 3+ species

Therefore, whether ferroptosis is beneficial for cancer immunotherapy remains unclear because of the contrasting results obtained to date immune checkpoint inhibitors have been used 84,115,116