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These precision editing modalities represent significant advances over conventional CRISPR-Cas9 nucleases, particularly in post-mitotic hepatocytes where HDR is inherently inefficient

10.1021/acs.jafc.3c06015 44 LiangZ.ChenY.XuL.QinM.YiT.ChenH.et al (2015)

This analysis indicates that the P

However, synthetic versions do exist and are produced by recombinant DNA technology

99,100,101 A study analysing 21 brain metastases and their matched primary breast cancer showed that BCBM tends to have high genomic-aberration-based-homologous recombination deficiency (HRD) scores compared with their primary tumour counterparts, which indicates that brain metastases might be more sensitive to PARP inhibitors than their corresponding primary tumours