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However, factors such as aging, poor diet, chronic stress, and environmental toxins can deplete glutathione levels, leading to increased oxidative stress and vulnerability to various health issues

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Nature 626, 401410

*Correspondence: Roberto Nisini, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

292 Exercise is a key part of combatting metabolic changes that begin in perimenopause and lead to decreased fat burning, weight gain, muscle loss, and increased abdominal fat accumulation