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Epigenetics in rheumatoid arthritis: a primer for rheumatologists

doi: 10.1021/acs.chemrev.0c00199 79 LeonardiI.ParamsothyS.DoronI.SemonA.KaakoushN

Inhibition of bcl-2 with liposomal-delivered antisense oligonucleotides (AS-ODN) induces apoptosis and increases the sensitivity of primary acute myeloid leukemia (AML) cells and cell lines to cytosine arabinoside and doxorubicin

Future approaches will require intelligent responsive nanocarriers and biomarker-based patient stratification to optimize the therapeutic window and facilitate clinical evaluation (78, 79)