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Targeted inhibition of NNMT improves insulin responsiveness and may protect against diet-induced obesity. Hong et al., Nature Medicine Longevity and Anti-Aging Potential Because NAD is vital for DNA repair, circadian rhythm regulation, and mitochondrial health, 5-Amino-1MQ is being explored as a geroprotective agent especially when stacked with NAD boosters or sirtuin activators

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doi: 10.1016/j.freeradbiomed.2023.05.027 34 De VitaSBoiocchiMSorrentinoDCarboneAAvelliniCDolcettiRet al

95% CI 2.1, 5.4%) developed systemic side-effects

30 min in a water bath at 37 C to form a homogeneous suspension