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Active site loop architecture is important in the efficient processing of small glucuronide substrates To explain the range of catalytic efficiencies exhibited by our panel of GUS enzymes, particularly the poor processing activity demonstrated by the new L1 GUS enzymes, we manually docked p NPG into the active site of each GUS enzyme (Figs 4 and 5)

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As in the case of grey matter imaging, individual variability may partly underlie this, and recent approaches that leverage individual heterogeneity can predict motor outcomes in PD with potential for individual-level predictions 153