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Since liver cirrhosis is often associated with increased oxidative stress and decreased antioxidant capacities, we conducted a double-blind randomized controlled trial to assess the antioxidative effect of vitamin B-6, GSH, or vitamin B-6/GSH combined supplementation in cirrhotic patients

Curr Opinion Toxicology 7:4451 Saleh AK, El-Mahdy NA, El-Masry TA, El-Kadem AH (2024) Trifluoperazine mitigates cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in mice by modulating the AKT/mTOR-driven autophagy and Nrf2/HO-1 signaling cascades

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Inappropriate hypermethylation leads to inactivation of tumor suppressor gene function and hypomethylation can result in oncogene activation