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[7] N-acetylated LKKTETQ (Ac-LKKTETQ) and several of its metabolites can be detected in equine urine and plasma following administration of TB-500 using liquid chromatographymass spectrometry, with metabolite profiling enabling identification of peptide-derived products in biological samples

A conserved serine residue (Ser167 in HPII) is also found to be hydrogen bonded to the N of the essential histidine and might facilitate the enzymatic mechanism [46]

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Physicians should consider reviewing all previous patient records to guide their diagnostic approach and narrow the differential diagnoses