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si-RNA, small interfering RNA

The use of the nutraceutical PROFERTIL a dietary management of the male factor, for the improvement of semen quality, EAU, Annual meeting, Abstract, Bratislava, Oct 2010

ARLD: alcohol-related liver disease BAs: bile acids CL: cardiolipin Cyt C: cytochrome c DAMPs: danger-associated molecular patterns Drp-1: dynamin-related protein 1 ER: endoplasmic reticulum ETC: electron transport chain FA: fatty acid FFA: free fatty acids GPX: glutathione peroxidase GSH: glutathione H 2 O 2 : hydrogen peroxide HCC: hepatocellular carcinoma HSCs: hepatic stellate cells IL: interleukin IMM: inner mitochondrial membrane IRF: interferon regulatory factor KCs: Kupffer cells MAMs: mitochondrial-associated membranes MASH: metabolic-associated steatohepatitis MASLD: metabolic dysfunction-associated steatotic liver disease MAT1A: methionine adenosyltransferase 1A mChol: mitochondrial cholesterol mGSH: mitochondrial glutathione mtDNA: mitochondrial DNA NLRP3: NLR family pyrin domain containing 3 O 2 : molecular oxygen O 2 : superoxide anion OMM: outer mitochondrial membrane OXPHOS: oxidative phosphorylation PC: phosphatidylcholine PE: phosphatidylethanolamine PGC-1: peroxisome proliferator-activated receptor gamma co-activator 1 Prx: peroxiredoxins PS: phosphatidylserine ROS: reactive oxygen species SAM: S -adenosylmethionine carrier STARD1: steroidogenic acute regulatory protein TG: triglycerides Trx: thioredoxin Cartoons in Figures were created with BioRender.com

2023;101:skad354

The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress