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Tissue Plasminogen Activator for preclinical stroke research: neither rat nor human dose mimics clinical recanalization in a carotid occlusion model

J Cell Mol Med (2019) 23:415364

Crucially, unlike apoptosis, which is typically immunologically silent, necroptosis results in cell lysis and the release of damage-associated molecular patterns, thereby provoking a potent inflammatory response (40)

Potential side effects include: Temporary blue or blue-green discoloration if too much product is applied (this washes off easily)

First, it turns down inflammation so it helps with things like redness and general upset skin