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At least three million Americans, or approximately 1% of the US population, have celiac disease, making it more than four times as common today than just 30 years ago (Lundin 2012

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As shown in Figure 4, mTOR is a critical factor in protein and glycogen synthesis, and it can be activated directly or through the activation of mTOR by PI3K and Akt (or by inhibiting TSC2, which positively regulates mTORC1 activity)

Finally, the absence of associations with BMI or patient group implies that this module captures intrinsic biological variation rather than overt clinical stratification