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For the aforementioned reasons, the maintenance of high concentrations of GSH is vital for most types of cell, since it plays important roles in the control of biological process, including metabolic detoxification, protein folding, vitamin regeneration, mitochondrial health, immune defense against viruses, cellular proliferation regulation, apoptosis, and redox balance, among others

However, its crucial to understand that no IV glutathione product is FDA-approved for skin lightening in any major regulatory jurisdiction, and the only placebo-controlled clinical trial showed poor efficacy with serious safety concerns

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Similar to reports in the gastrointestinal and respiratory tract, substance P has been shown to augment inflammation in the CNS (Lee et al., 1994