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Hydroperoxides (ROOH) Hydroperoxides are unstable compounds formed via lipid (LOOH), protein (POOH), and DNA oxidation, originating primarily from three hepatic sources: (1) electron leakage from the mitochondrial electron transport chain (particularly Complex I/III), (2) ROS-generating activity of CYP2E1, and (3) the NOX enzyme family (predominantly NOX4)

Identifying such early metabolic alterations may ultimately guide the development of biomarkers for HAND risk stratification and enable timely intervention

In K2, DEs were of an early manifestation and tended to a protracted course without obvious seasonality of their development

One-carbon metabolism nutrients impact the interplay between DNA methylation and gene expression in liver, enhancing protein synthesis in Atlantic Salmon

Cochrane Database Syst Rev (2014) (3):Cd005228