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First, the acceleration of early improvement is clinically meaningful for patients with time-sensitive goals

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Despite being quadrupedal for locomotion, cynomolgus monkeys also spend large amounts of time in semierect and erect positions and exhibit characteristics that more closely mimic humans, including IVD size, anatomy, spontaneous disc degeneration, and exposure to mechanical stresses compatible with erect posture

Taken together, these data point to a disruption of the intestinal epithelial barrier function early in the course of RA development