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In this protocol, we favor a functional definition of SLP dependency as the comparatively limited capacity of malignant cells to sustain long-term proliferation when forced to use OXPHOS-exclusive metabolism (e.g., deprivation of glucose and glutamine, the two primary SLP fuels, at the substrate, transport, or utilization level)

Clinical studies indicate minimum 2% concentration is required for measurable melanin inhibition

Angiogenesis inhibitors: A type of targeted therapy that is being studied in the treatment of melanoma

Signal transducer and activator of transcription 3 (STAT3) binds to DNA response elements in the promoters of ferroptosis-related genes (FTH1, SLC7A11, and GPX4) and regulates their expression