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In the context of DILI, apoptosis is initiated through the intrinsic pathway due to the generation of ROS, leading to a cascade of events that ultimately results in mitochondrial outer membrane permeabilization (MOMP) [30]

& Stryer, L

For example, GSHresponsive sonosensitizer nanoparticles first deplete tumor GSH levels and then release a burst of ROS, amplifying oxidative stress and promoting immune activation [297]

After filtration and centrifugation, the cell pellet was resuspended with low glucose Dulbeccos modified Eagles medium (DMEM, Gibco) containing 10% fetal bovine serum (FBS, Gibco) and 1% penicillinstreptomycin (Gibco) at 37 C and 5% CO2 in 10-cm dishes

Nevertheless, even if 85% of patients with cirrhosis in another study had a pathological LMR, the test failed to predict the development of SBP or survival (144)