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This small molecule, with a molecular weight of approximately 403.9 Da for the free peptide (or ~467 Da as the copper complex), is found at concentrations of approximately 200 ng/mL in young adults, declining significantly with age

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Consistent with the role played by ZIP14 in regulating glucose-lipid metabolism, induction of ZIP14 in hepatocytes also assumes a relevant role in adaptation to ER stress induced by high-fat diet (HFD)

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