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doi: 10.1146/annurev-biochem-052610-091920

Nature 572 , 397401 (2019)

Its neuropathological hallmarks include amyloid-beta (A) plaque deposition, NFTs composed of hyperphosphorylated tau protein, cerebral amyloid angiopathy, neuroinflammation, and progressive neurodegeneration (284)

In spite of the association between Fragile-X Syndrome and Amyloid Beta Precursor Protein expression 42,43,44 , no bb-CpG with differential methylation found in AD patients was differentially methylated in Fragile-X patients