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The structural integrity of the mucosal linings in the gut and respiratory tractwhere mast cells are highly concentratedis also compromised when sulfur levels are low, making these tissues even more reactive to environmental triggers

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Conversely, it increases genes associated with vascular injury or angiogenesis, such as platelet glycoproteins GP5 and GP9, suggesting that 16-OHE may induce inflammation through noncytokine pathways, although the precise mechanism remains unclear [41]

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