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These findings indicate that PDEIs can positively impact cortico-striatal transmission by increasing cyclic nucleotide levels in striatal neurons, which can lead to neuroprotection (Colwell and Levine 1995

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Deleting or inhibiting the Group I mGluRs in rodents is associated with a reduction in learning and memory-associated tasks such as the Morris water maze task, which was the first evidence for the function of mGluR5 receptors in spatial learning using mGluR5 receptor knock-out animals [29]

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