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A review of global health data underscores the gravity of the situation: cardiovascular diseases have become the leading cause of global mortality, accounting for nearly 18 million deaths annually (Roth et al., 2020)

Shmerling, MD, Senior Faculty Editor, Harvard Health Publishing Data on life expectancy in the United States (U.S.) has been collected since 1900 and, with rare exceptions, has consistently increased

As a scavenger of toxic free radicals, GSNO is 100-fold more potent in neutralizing ROS than GSH and is further metabolized by an evolutionary conserved enzyme S-nitrosoglutathione reductase (GSNOR) at the expense of NADH to generate GSSG and ammonia (Figure 3)

This immunosuppression may be associated with increased susceptibility to viral, protozoal, and fungal infections

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