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Intramuscular administration of aripiprazole lauroxil to rats and dogs was associated with injection site tissue reactions at all doses in rats treated up to 6 months at doses of 15, 29, and 103 mg/animal (which are approximately 0.3 to 2 times and 0.5 to 3 times the MRHD of 1064 mg on mg/m2 basis in males and females, respectively) and in dogs treated up to 9 months at doses of 147, 662, and 2058 mg/animal (which are approximately 0.5 to 6 times and 0.6 to 8 times the MRHD in males and females, respectively on mg/m2 basis)

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This provides a novel approach and pathway to shield cells from ferroptosis (79, 80)

Aging 6:788819 Kaliuzhka V, Tkachenko A, Myasoedov V et al (2023) The Prognostic Value of Eryptosis parameters in the cerebrospinal fluid for cerebral vasospasm and delayed cerebral ischemia formation

MicroRNA modulators of epigenetic regulation, the tumor microenvironment and the immune system in lung cancer