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Additionally, a loss of thioredoxins or thioredoxin reductase results in a threefold increase in the concentration of reduced GSH

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Durak , zbek H, Karaayvaz M, ztrk HS (2002) Cisplatin induces acute renal failure by impairing antioxidant system in Guinea pigs: effects of antioxidant supplementation on the cisplatin nephrotoxicity

The changes presented here directly influenced selenoprotein expression and host antioxidant metabolism