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3,1014 In a large study 10 of 406 patients with known vitamin B 12 deficiency, 98.4 percent had elevated serum methylmalonic acid levels, and 95.9 percent had elevated serum homocysteine levels (defined as three standard deviations above the mean)

Transcriptional control of mitochondrial biogenesis: The central role of PGC-1

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doi: 10.3389/fncel.2024.1426231 Received 01 May 2024 Accepted 14 June 2024 Published 05 August 2024 Volume 18 - 2024 Edited by Wensheng Lin, University of Minnesota Twin Cities, United States Reviewed by Zhixin Lei, Wuhan University of Technology, China Carlos Matute, Achucarro Basque Center for Neuroscience, Spain Updates Copyright 2024 Stys, Tsutsui, Gafson, t Hart, Belachew and Geurts

Studies indicate that NNMT inhibition by compounds such as 5-Amino-1MQ can result in reduced fat mass and improved insulin resistance