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This review summarizes the pathogenesis of IBD, including intestinal mucosal immune dysregulation, intestinal barrier damage, gut microbiota dysbiosis, reactive oxygen species (ROS) homeostasis imbalance, and the complex crosstalk between genetic and environmental factors

10 mg kg 1 ) caused an immediate decrease in the mean arterial blood pressure of the anaesthetised rats, which was inhibited by L-NAME (Kang et al., 2007)

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