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According to studies in animal models of glaucoma, the progressive RGCs death occurs mainly via apoptosis triggered by several interrelated mechanisms, including mechanical stress and impaired axonal transport of neurotrophic factors, glutamate excitotoxicity, as well as retinal ischemia and oxidative stress 8

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E., Sudderth, J., Yue, Y., Zia, A., Glass, D., Deberardinis, R