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For instance, SNpc samples from individuals with iPD show significantly decreased activity of mitochondrial complex I relative to controls [50], while PD astrocytes exhibit reduced expression of complexes I-V [51]

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Therefore, taken together, these limitations reflect the need for developing a more accessible and simpler assay that can measure the rate of NADPH consumption by a specific pathway, such as the one mediated by glutathione-disulfide reductase (GSR)

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