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J.AbdelmegeedM

In normal liver cells, TMA is oxygenated back to the odourless TMAO by the microsomal flavin-containing monooxygenase FMO3

In a pilot study of 55 ME/CFS patients, a 41-day course of oral minocycline (100 mg/day after a loading dose) resulted in favorable symptom improvements for 80% of treatment completers, reflected in better performance status and ADL scores, with a notably higher success rate (90%) observed when treatment was initiated within six months of onset [158]