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Limiting serine availability during tumor progression promotes muscle wasting in cancer cachexia

Taking Pramlintide as an example, it is a synthetic analog of human insulin composed of 31 amino acids

Li Z, Qian D, Yumin H, Zihan W, Wenjuan D, Yang L, Yueping D, Hongpeng W, Shaomin S, Chuan D, et al

for example, turning on tumor suppressor genes

These nanocarriers typically possess pH-sensitive chemical bonds or functional groups that undergo protonation or deprotonation, leading to a charge switch from negative to positive