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doi: 10.1016/j.brainres.2022.148022 146 CaliCPParkDSLeeEB

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Thyroid Hormones Roles and Functions T3 and T4 affect [1]: Breathing Metabolism Heart rate The nervous system Bodyweight Muscle strength Menstrual cycles Body temperature Cholesterol levels Growth and development Intestinal flow Digestion Metabolism T3 changes gene expression (cellular production of certain proteins and hormones) of multiple metabolism-related genes

Cellular targets of SAMe transmethylation pathways pertinent to mental/neurological diseases SAMe and DNA Methylation Status DNA methylation, as an epigenetic mechanism, plays a pivotal role in the regulation of gene transcription and the establishment and maintenance of cellular identity [31], which is disrupted in many diseases