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The procedure is quick, typically taking just a few minutes, and there is minimal discomfort

How to break an ampoule safely

Biochemistry 38, 1535215359

So, we recommend using SL vitamin B12 rather than oral and IM, especially in patients who do not tolerate IM injection and patients who need prolonged vitamin B12 supplementation, such as patients with long-term metformin use and patients with pernicious anemia or with gastro-duodenal resection [51,52,53,54]