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Clinical pharmacokinetics of metformin

Danza, G

Studies have demonstrated its ability to stimulate collagen and glycosaminoglycan synthesis, attract immune cells to sites of injury, and modulate gene expression related to tissue remodeling

This 1500-fold increase in rate allows for the cell to respond to external signals with high speed, as well as spatial resolution due to limited amount of second messenger that can be generated and limited distance a G-protein can diffuse in 0.03 seconds

94 Polymorphisms and mutations in the NFKB1 gene, which encodes the IB-like molecule p105 and its processing product p50, have also been associated with IBD