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IGF-I/IGF-IR signaling in osteoclasts Studies of global IGF-I KO mice showed fewer (76% of WT control) and smaller osteoclasts with fewer nuclei in the bone (65), indicating impaired osteoclastogenesis and bone resorption (Figure 2)

Most of the studies examining neural function in the euthymic state have noted decreased function in ventrolateral PFC, dorsolateral PFC, and hyperactivation of striatal regions (caudate and putamen) (106)

RA not only causes inflammatory arthritis, but additionally causes extra-articular symptoms, which include inflammation in the skin, eyes, lungs, heart, blood vessels, and other organs [3, 4]