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First, the crosstalk network between distinct ferroptosis-regulating pathways (System Xc GSHGPX4 axis, lipid peroxidation, iron metabolism, and epigenetic regulation) remains poorly definedwhether these pathways act in a hierarchical, synergistic, or compensatory manner in different phases of I/R injury (ischemia vs

238 studied genes related to glutaminolysis in order to determine the sensitivity of glutamine metabolism to xCT-targeted therapy in head and neck squamous cell carcinoma

Deeply elucidating these immune mechanisms is essential for developing novel prevention and treatment strategies

Oxidative Stress & Detoxification Burden: Toxins from the pathogens themselves, as well as byproducts of the immune response, can overload the bodys detox pathways (especially liver and lymphatic systems), leading to cellular damage and inflammation

In cell culture models of human macrophage foam cells, the inability to clear cholesterol from macrophages with compromised lysosome function continues even in the presence of compounds that stimulate efflux (161,163)