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Enhanced bioavailability means higher systemic exposure to curcumin, which can potentially amplify its anti-inflammatory and antioxidant effects, thereby improving its therapeutic impact [87]

Although several GlyT1 inhibitors have shown adequate brain penetration in both preclinical and clinical studies, determining the extent to which these compounds elevate glycine concentrations within specific synaptic microdomains in vivo remains challenging

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It was required to incorporate dose less than or equal to 20 mg per patch and still deliver at least sufficient amount at the end of 24 hrs considering half-life of around or less than 2 hrs

22 Molecular modeling using Schrdinger Maestro further confirmed these findings, providing deeper insights into the binding interactions between Osimertinib, CP-24, and DDRGK1