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Trace elements in human nutrition (II) - an update

Interestingly, a number of intracellular proteins that can be released and act as endogenous inflammatory signalling molecules (also known as damage-associated molecular patterns) can undergo glutathionylation, including high mobility group box 1 protein (HMGB-1) 14 , proteins of the S100 family 15 , galectin-1 16 , peroxiredoxin-2 (Prdx2) 17 and heat-shock protein 70 (HSP70) 18

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Furthermore, LXA4 downregulates HIF-1 expression, limiting hypoxia-driven angiogenesis and restraining tumor progression [225]

Each one targets a different skin goal