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Key citation: Bhatt DL et al., Washington State University preclinical models demonstrating Dihexas HGF/c-Met-mediated synaptogenic activity

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Several pieces of evidence suggest oligomerization is essential for the transport of DAT from the endoplasmic reticulum (ER) to the plasma membrane during synthesis (Sorkina et al., 2003

Cagrilintide vs semaglutide (Wegovy/Ozempic) Mechanism: Cagrilintide: Amylin receptor agonist Semaglutide: GLP-1 receptor agonist Different pathways Weight loss: Cagrilintide alone: 10-12% Semaglutide alone: 10-15% Similar efficacy monotherapy Gastric emptying: Cagrilintide: Very strong delay Semaglutide: Moderate delay Cagrilintide more powerful Side effects: Cagrilintide: More GI effects (stronger gastric slowing) Semaglutide: Moderate GI effects Cagrilintide harder to tolerate for some Availability: Cagrilintide: Investigational (not approved) Semaglutide: FDA approved, widely available Semaglutide easier to obtain currently Combination potential: Synergistic together (CagriSema) 15-25% weight loss combined Best of both mechanisms Verdict: Similar monotherapy efficacy, but combine for maximum results

Notes Chill for best flavor: The dip tastes good right away, but the flavors really come together after chilling