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The hepatoprotective effect of Lycium barbarum (wolfberry) has been documented in China for thousands of years, and Lycium barbarum polysaccharide was the first reported macromolecule shown to alleviate liver fibrosis in CCl-treated mice [278]

In-vitro testing of the ABS-75 compound also supported its neuroprotective and antioxidant properties, partly by preventing glutamate-induced damage to neurons and restoring glutamine synthetase and glutamate transporter expression in astrocytes under neuroinflammatory conditions

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After treatment with -ketoglutarate (-KG), mitophagy flux increased, mitochondrial structure and function significantly improved, ROS production was inhibited, and OA was improved through the alleviation of chondrocyte apoptosis [268]