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(2021) 9:e003973

Satoh and Yoshioka, 2006), which is considered a more sensitive indicator of oxidative stress than GSH alone

Reduced intracellular glutathione levels removes the inhibition of -glutamyl cysteine synthetase and synthesis of -glutamyl cysteine increases (Figure 2, reaction 4)

(1), where I represents fluorescence emission following excitation at 400 or 480 nm, for the fully oxidized (ox), fully reduced (red) and experimental samples (sample), respectively

Glutathione is a potent antioxidant that plays several essential roles in the body, from neutralizing free radicals to supporting cellular repair and recovery from damage