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This compound must be handled exclusively by qualified professionals in controlled laboratory environments in accordance with applicable regulations and safety guidelines

Cuprizone induces mitochondrial injury and oxidative stress by increasing mitochondrial production of superoxide anions 4 , reducing copper-dependent cytochrome c oxidase and monoamine oxidase activity 1 , decreasing copper-zinc superoxide dismutase 5 and glutathione 6 antioxidant activity, and inhibiting electron transport chain complex IV 7

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Necrosis is usually absent

Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist