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1) GSHGPX4 antioxidant system in the cytosol and mitochondria: One of the most critical defenses against ferroptosis is the GSHGPX4 system located in both the cytosol and mitochondria (101)

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An isolated antibody that specifically binds to FRa may, however, have cross-reactivity to other antigens, such as FRa molecules from other species