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Notably, familial PD mutations share the capacity to enhance kinase activity, either directly via the kinase activation loop (G2019S, I2020T) or indirectly via the Roc-COR tandem domain (R1441C/G/H, Y1699C) presumably by impairing GTP hydrolysis and prolonging the GTP-bound state [12, 13]

1 China is one of the countries with the fastest aging rates in the world, and the proportion of people aged 60 and above is expected to reach 28% by 2040

Zhu B, Li Y, Xiang L, Zhang J, Wang L, Guo B, Liang M, Chen L, Xiang L, Dong J, Liu M, Mei W, Li H, Xiang G (2019) Alogliptin improves survival and health of mice on a high-fat diet

The FDA classifies it as a Category 2 bulk drug substance, noting potential safety concerns in unregulated compounding

DEGs were identified using the DESeq2 [52] package in R