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But, notably, 24 h treatment of NSBSO showed strong cytotoxicity against MCF-7, B16, A549 and 4T1 cells, with IC 50 values of 1.074, 0.844, 1.222 and 4.741 M, respectively, which were much lower than those of reported GSH-responsive peptide derivatives whose IC 50 was greater than 100 M [43]

Thus, the critical challenges to further potentiation of the efficacy of fasting are to identify tumors for which the greatest benefits of fasting can be achieved and to elucidate the underlying molecular mechanisms

This suggests that FM patients may have difficulty staying alert and focused, which could contribute to FM-related fatigue and cognitive impairment

Tight junction proteins are the main components of the intercellular junctions that play a critical role in epithelial cells