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GavriatopoulouMKastritisENtanasis-StathopoulosIFotiouDRoussouMMigkouMet al.The addition of IMiDs for patients with daratumumab-refractory multiple myeloma can overcome refractoriness to both agents

Vitamin B12 plays a role in gluconeogenesis or the production of glucose by the liver

The mutation in ALDH4A1 leads to the accumulation of pyrroline-5-carboxylate (P5C) in the mitochondria, which can react with PLP to cause PLP deficiency in the brain and can also be converted to proline, resulting in elevated plasma proline levels (Fig

These dual metabolic interactions make NNMT a uniquely positioned research target

Like semaglutide, it reduces food intake and appetite by mimicking hormones