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also antiviral Side effect: Livedo reticularis (mottled skin rash) 5

The exposed caspase recruitment domain (CARD) then recruits and activates the initiator caspase-9, which subsequently cleaves the effector caspase-3, triggering apoptosis (66)

Nevertheless, since the risk of cardiovascular and renal events will remain even with the use of GLP-1RA, there is a great deal of clinical interest in its combined use with SGLT2i and finerenone (Table 4)