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thus, they can detoxify various harmful substances including reactive oxygen species (ROS) ( GSTP1 gene is located on chromosome 11 (11q13) ( GSTP1 genetic variants are the rs1695

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doi: 10.1073/pnas.1507228112 157 NicklinPBergmanPZhangBTriantafellowEWangHNyfelerBet al

A42 with its Tyr-10 substituted by phenylalanine would keep the aromatic nature of the side chain at residue 10 of A but lack the OH group of Tyr that was purported by others to be the source of the free radical of A42

They interfere with signal transduction in melanocytes, leading to the death of these cells and acting as a mediator of the damaging effects of oxidative stress [22]