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Since muscle burns more calories than fat, losing muscle makes weight loss harder and weight gain easier

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Notably, the requirement for INTS12-mediated Pol II removal is context dependent, as it is not advantageous during the transcription-coupled response to formaldehyde-induced DNAprotein crosslinks, which rely on a distinct proteasome-dependent degradation pathway

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Secondly, the acetylation in the N-terminal region, shown to impair autoproteolytic processing, would ensure a binding of SnCE1 to the vacuole membrane in early phases of infection upon exposure of SnCE1 to the host cell