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Chronic kidney disease patients often demonstrate elevated B12 levels, particularly those on dialysis

3.5 Meta-analysis The included studies showed substantial heterogeneity (I 2 = 99.6%, p 0.05), supporting the conclusion of comparable efficacy and the lack of a clear doseresponse relationship

Current models do not fully explain the mechanisms underlying resistance to therapy ( + MM cells within hours to days after the first infusion ( Figure 6 ), underscore the need to further investigation into the CD38/ADA/purinergic axis to optimize anti-CD38 strategies in MM

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Inflammation eliminates and repairs damaged cells